Finding valuable tools to help manage the COVID-19 pandemic is an essential part of our research. One of the most accessible points to stop the virus is in the upper airway. Listen to innovative solutions from presenters across the world:
Marcos A Sanchez-Gonzalez (Dr Ferrer BioPharma) – USA
Debbie Black (Bionic Air) – Australia
Vanya Loroch (Novochizol) – Switzerland
Stan Lech (Clover Hill Healthcare) – USA
John Ables – USA
Christopher Newton – UK
Jennifer Smith – Hawaii
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Geert Vanden Bossche PhD, is an internationally recognised vaccine developer having worked as the head of the Vaccine Development Office at the German Centre for Infection Research. Coordinated Global Alliance for Vaccines and Immunisation’s Ebola Vaccine Program and contributed to the implementation of an integrated vaccine work plan in collaboration with Global Health Partners (WHO, Bill & Melinda Gates Foundation, CDC, UNICEF), regulators (FDA) and vaccine manufacturers to enable timely deployment or stockpiling of Ebola vaccine candidates.
Highlighting the principle of using a prophylactic vaccine in the midst of a pandemic. Likely to create more more viral variants in the process.
Sharing his perspective on mass vaccination in COVID-19.
Macrophage Activation Syndrome in COVID-19 was being discounted at the time when I heard it first. It remained unexplained for over a year and finally made sense when I reflected on the consistent elevation of ferritin in most severe cases.
The delayed interferon response to SARS-COV2 which occurs in people without prior coronavirus (not just COVID-19) exposure, causes an accumulation of immature monocytes in lung tissue.
Once the immune system has been activated to target ACE-2 (autoimmune response), autoantibodies will then cause widespread monocyte activation, primarily in the lungs.
This concept is important to understand as we are likely to see different disease presentation, eg, kidney and heart disease, in those who have elevated serum ACE-2 and were previously vaccinated.
In unclear cases, we can measure the ferritin and if 5 to 10 times above normal, consider steroids to treat possible Macrophage Activation Syndrome.
McMillan Research does not currently have real world evidence data regarding all aspects of autoimmunity in COVID-19. The theory of autoimmunity in COVID-19 could form the basis for clinical investigation and medical monitoring. There are many challenges associated with clinical trials, especially clinical human trials. A clinical trial study requires a comprehensive development plan, and may use clinical biostatistics. A centre for clinical research focused on long COVID, could potentially provide much needed solutions.