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Factors contributing to immune escape in COVID-19 explained by Geert
  • Mass vaccination during a pandemic led to immune escape in COVID-19. 0:31

  • Evolution of new variants started with mass vaccination programs. 0:45

  • Antibody responses induced by Omicron were not protective against new variants. 1:09

  • Virus evolved to higher infectious strains due to vaccination responses. 1:39

  • This phenomenon applies to pandemics of acute self-limiting viral infections. 2:06

Factors contributing to increased severity of COVID-19 and immune escape mechanisms
  • Decreased vaccination rates lead to reduced protection from antibodies. 2:50

  • Virus can develop glycosylation changes to bypass inhibiting antibodies. 3:26

  • Diminished antibody levels make it easier for virus mutants to overcome immunity. 4:08

  • Sub-optimal pressure on the virus may lead to evolution of glycosylation profiles. 5:03

  • Importance of analyzing glycosylation evolution in current variants. 5:30

Understanding the Decline in Virulence Inhibiting Antibodies and its Impact on Immune Pressure on the Virus
  • Decrease in virulence inhibiting antibodies may reduce immune pressure on the virus. 6:01

  • Boosters or revaccination may help increase antibody levels to control virulence. 7:02

  • Current boosters and vaccinations may not effectively boost vaccine-induced antibodies. 7:28

  • Surveys on antibody levels in vaccinated populations are needed to assess immunity. 7:46

  • Ongoing monitoring and research are crucial to address immune escape in COVID-19. 8:10