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Potential Clinical Implications of Viral Shift Predictions – Only Geert’s Thoughts

May 1, 2024 | COVID-19, Geert Vanden Bossche, Immune Response, Public Health Policy, Research, Vaccination

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Implications of evolving virus on herd immunity and vaccine effectiveness

  • Virus evolution due to lack of herd immunity. • 0:00

  • Immune pressure driving virus mutations. • 2:04

  • Concern over mutations affecting virus infectiousness. • 3:54

  • Shift in immune pressure from spike protein to overall infectiousness. • 4:25

  • Dominance of highly infectious viral strains like gn1. • 4:41

  • Lack of proof on increased infectiousness being less harmful. • 5:01

  • Increased prevalence of gn1 in multiple countries. • 5:01

Implications of viral shift predictions on increased virulence due to declining non-neutralizing antibodies

  • Recent findings suggest the virus is more fusogenic, potentially leading to increased virulence. • 5:15

  • Antibody-dependent enhancement of infection may impact both infectiousness and protection against virulence. • 6:03

  • Declining concentrations of non-neutralizing antibodies could result in enhanced virulence and virence. • 6:55

  • The virus may shift towards enhanced virulence to ensure continued propagation within the body. • 8:07

  • Predictions indicate a potential massive change in the virus to overcome immune pressure. • 8:41

  • Immune mechanisms currently in place may not be sustainable in the long term. • 9:21

  • Decline in immunity is gradual and not sudden, affecting the entire population. • 9:42

Implications of viral mutations on immune defense mechanisms and potential for severe disease outbreak

  • Viral mutations occur to overcome residual defense mechanisms in the population. • 10:24

  • Highly virulent viruses can cause severe disease in the absence of sufficient immunity. • 12:29

  • Global availability of safe and affordable antivirals is crucial for prevention. • 13:28

Implications of possible viral mutations, lack of plan B, and concerns over complex solutions

  • Multiple approaches to antiviral drugs needed for efficacy. • 14:44

  • Warning about pandemic preparedness given past experiences. • 15:27

  • Concern over lack of feedback and corrective actions in response to warnings. • 16:00

  • Perceived artificial complexity in managing pharmaceutical solutions. • 17:24

  • Growing panic among experts about unpredictable virus changes. • 18:35

  • Absence of contingency plan in case of unfavorable virus evolution. • 19:04

Urgent call for immediate action in response to potential viral shift predictions and vaccine breakthrough infections

  • Scientists urged to collaborate on viable models considering multiple disciplines. • 19:40

  • Notable increase in vaccine breakthrough infections, signaling a potential upcoming wave. • 21:06

  • Advocacy for prophylactic treatment with antiviral drugs like hydroxychloroquine. • 21:30

  • Emphasis on the need for immediate action rather than waiting for further developments. • 22:07