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Will the Omicron Variant BA2.86 Evade Vaccines? - McMillan Research Limited
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Will the Omicron Variant BA2.86 Evade Vaccines?

May 25, 2024 | COVID-19, Research, Treatment

Discussion on the potential immune evasion of the Omicron variant BA2.86 and the importance of preparing for contingencies in the pandemic.

  • Dr. Philip McMillan discusses the immune evasion potential of the Omicron variant BA2.86. • 0:04

  • Offering a free session on preparing for the next wave of the COVID pandemic. • 0:55

  • Emphasis on preparing for contingencies in the face of uncertainties in the pandemic. • 1:10

  • Highlighting the importance of anticipating potential risks and taking proactive measures. • 1:17

  • Encouragement for questioning and seeking information to be better prepared. • 1:25

  • Previous experience in developing a plan for the elderly in Care Homes during the early stages of the pandemic. • 1:51

  • References to previous research and strategies considered for high-risk groups during the pandemic. • 2:00

Emergence of highly immune invasive Omicron variant BA2.86 raises concerns about vaccine efficacy.

  • Senior news reporter highlights the seriousness of Omicron subvariant BA2.86. • 2:46

  • BA2.86 variant detected in the UK, more likely to cause severe illness. • 3:04

  • Comparison between Delta and Omicron variants shows significant differences in mutations. • 4:19

  • Discovery newspaper describes BA2.86 variant as highly immune invasive and antigenically different. • 5:07

Analysis of Omicron variant BA2.86 suggests potential challenges for vaccines and immunity.

  • BA2.86 variant differs from previous Omicron variants and may resist immunity induced by vaccines. • 5:57

  • BA2.86 is highly immune invasive and acquiring additional mutations during transmission. • 6:08

  • Importance of closely monitoring BA2.86 due to its potential impact on the pandemic. • 6:25

  • Vaccines focused on spike protein may struggle against variants like BA2.86. • 7:06

  • Natural infection provides broader immune response against various viral proteins. • 7:32

  • Virus evasion of immunity and infection process illustrated through nasal passages to lungs. • 7:50

Concerns about the Omicron variant's evasion of vaccines and potential impact on vaccinated individuals.

  • Injectable vaccines may not strengthen mucosal immunity, leading to lower protection against reinfection. • 8:22

  • Vaccinated individuals still show a significant cumulative incidence of COVID infection. • 9:01

  • The Omicron variant favors a specific viral entry mechanism using A2 and endosomes. • 9:58

  • Highly evasive variants infecting vaccinated individuals pose a significant concern. • 10:30

  • Autoimmunity as a primary mechanism for disease is a topic of debate in the scientific community. • 10:49

Concerns raised about potential autoimmunity triggered by Omicron variant BA2.86 and vaccine evasion.

  • Proteins binding to spike protein may cause autoimmunity. • 11:03

  • High circulating virus and poor mucosal immunity in vaccinated individuals. • 11:11

  • Challenge of preventing virus from entering bloodstream to avoid autoimmunity. • 11:32

  • Importance of considering contingencies and being prepared. • 12:12

  • Encouragement to join upcoming webinar for more insights. • 12:31